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What are the benefits of taking magnesium glycinate?

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Magnesium glycinate is a busy mineral that supports bone health, digestion and memory. Curious about its potential benefits? Discover why this form of magnesium is a supp worth considering

Summary

1What is magnesium glycinate?

Magnesium glycinate (also known as magnesium bisglycinate or magnesium diglycinate) is a type...

2Benefits of taking magnesium glycinate

It may boost memory. Studies have found that magnesium glycinate can help lessen...

3What does magnesium glycinate do?

Magnesium supplements can help people who are deficient in it up their levels. A deficiency is...

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Looking for a magnesium boost that does more than just build bones? Meet magnesium glycinate, the multitasking mineral here to support your digestion. hormones and memory. Curious about how this magnesium marvel works? Let's find out more.

What's magnesium glycinate?

It’s a form of magnesium. So, for instance, you can get magnesium sulphate, which is usually taken via injection or IV for extreme magnesium deficiencies. You can also soak in it, as this form of magnesium is used to make Epsom salts.1

Magnesium citrate can help improve digestion; magnesium oxide can help with heartburn, and magnesium chloride can potentially soothe skin issues.2 Magnesium hydroxide (Milk of Magnesia) can help with constipation.1

Magnesium glycinate (also known as magnesium bisglycinate or magnesium diglycinate) is a type of organic magnesium salt or amino acid chelate that’s created by combining inorganic magnesium with an amino acid called glycine. 

Glycine is the smallest amino acid. It happens to be so small it can squeeze through the tiniest spaces. It plays a significant role in collagen and elastin formation, as well as bile acid function, and acts as a neurotransmitter in the central nervous system.3 

Being deficient in glycine may result in growth impairment and immune and nervous system problems.4
Holland & Barrett Magnesium Bisglycinate 375mg 90 Capsules

Supports normal muscle function

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€0.21/1 Capsules

What are the benefits of taking magnesium glycinate?

So, we know by now there are various forms of magnesium, all with their own properties. But what are the top magnesium glycinate benefits?5  

Magnesium glycinate alone can potentially benefit the body in so many ways, ranging from easing PMS symptoms, leg cramps, headaches and migraines, to helping with bone health, blood sugar levels and boosting concentration and memory. Here's the rundown...


What does magnesium glycinate do?

Magnesium supplements can help people who are deficient in it up their levels. Magnesium deficiency is one of the more common deficiencies, with half of the total population in the US being deficient in this mineral.15 

Around 60% of the magnesium that’s found in the human body is within your bones. The rest is in your body tissues and around 1% is in your blood.2 

Magnesium is essential in the human body for:16 
  • turning the food we eat into energy 
  • making sure our parathyroid glands, which produce hormones important for bone health, work properly
According to the NHS, the recommended daily allowance is: 
  • 300mg a day for men (19 to 64 years) 
  • 270mg a day for women (19 to 64 years)

Magnesium can be found in food such as spinach, wholemeal bread and nuts.

What’s the difference between magnesium and magnesium glycinate?

As we touched upon earlier, magnesium glycinate is actually just a type of magnesium.

Magnesium glycinate is classed as the organic magnesium salt of glycine, which is made when combined with inorganic magnesium salts. But when we refer to magnesium more generally (i.e., magnesium supplements), we’re often talking about magnesium oxide or Milk of Magnesia, which is classed as inorganic.17

While pure magnesium oxide supplements contain more magnesium, studies have shown that it may not be absorbed by the body as well as magnesium glycinate.18,19

Magnesium and vitamin D

Magnesium glycinate helps our bodies to function properly, particularly when it comes to making sure we have enough energy, and our bones are healthy. One of the ways we can boost our magnesium is through our diet, with good food sources, including flaxseed, tofu, and almonds.
Happy diverse group of friends enjoying dinner barbecue in summer at home terrace.
Low magnesium levels can also make vitamin D inefficient in our bodies. This is because vitamin D cannot be metabolised without sufficient magnesium levels. 

One study found that patients with optimum magnesium levels required less vitamin D supplementation to achieve sufficient levels. Deficiency in either magnesium or vitamin D is associated with disorders including skeletal deformities, cardiovascular diseases and metabolic syndrome.15

What are the best magnesium glycinate supplements?

If you’re interested in trying some magnesium glycinate supplements, it’s worth considering a few factors before you choose one. This includes: 
  • the format – if tablets aren’t your thing, why not try some magnesium glycinate powder? 
  • the strength – if you’re just starting out with taking magnesium, you may want to try a lower dose first 
  • added ingredients – do you want to take magnesium with added zinc, calcium or vitamin D
  • lifestyle factors – if you’re vegan or coeliac, ensure you get the supplements that fit in with your needs

What magnesium glycinate side effects can happen after having too much?

Excessive magnesium levels can lead to stomach upsets, nausea, vomiting and diarrhoea, because almost all forms of magnesium can have a laxative effect.1 

Too much magnesium can also lead to low blood pressure, drowsiness, muscle weakness, slow breathing, and possibly even death in some circumstances. 

If you have kidney disease, you should not take magnesium unless instructed to do so by a medical professional. Magnesium can also interact with certain medications, such as blood thinning and anti-diabetes medication, and should be taken at least two hours apart from these medications.

Does magnesium glycinate help you poop?

As we’ve just mentioned, the one thing that most forms of magnesium have in common, is they can have a bit of a laxative effect.

This is because magnesium draws water into the intestines. The increase in water stimulates bowel motility. It also softens and increases the size of the stool, triggering a bowel movement and helping to make stools easier to pass.

The final say

Magnesium glycinate is just one form of the mineral, magnesium, which plays an essential role in the human body. Not only is it key for turning the food we eat into energy, but it’s an important contributor to bone health. 

There are more specific benefits linked to this type of magnesium, which include helping with blood sugar and blood pressure levels and boosting memory, to name but a few. 

Want to learn more? We've put together a magnesium myth-buster, with the help of our in-house expert.

Disclaimer – This article provides informational advice and is not a substitute for medical care. Curated by experts for accuracy, we take great care to ensure the information is up-to-date and relevant. However, you should always consult your GP or healthcare professional before using supplements or alternative products, particularly if you have medical conditions or are under supervision.

Sources

1. ConsumerLab. What are the side effects of magnesium supplements? ConsumerLab.com. 2024 [cited 2025 Sep 29]. Available from: https://www.consumerlab.com/answers/what-are-the-side-effects-of-magnesium-supplements/magnesium-side-effects/ 
2. National Institutes of Health. Magnesium [Internet]. National Institutes of Health. 2022. Available from: https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/ ‌
3. About magnesium glycinate (glycine). Natural Calm Canada. 2024 [cited 2025 Sep 29]. Available from: https://naturalcalm.ca/about-magnesium-glycinate-glycine/ 
4. National Organization for Rare Disorders. Arginine:glycine amidinotransferase deficiency. NORD. 2024 [cited 2025 Sep 29]. Available from: https://rarediseases.org/rare-diseases/argininie-glycine-amidinotransferase-deficiency/ 
5. Magnesium glycinate: benefits, dosage & side effects. MindBodyGreen. 2024 [cited 2025 Sep 29]. Available from: https://www.mindbodygreen.com/articles/magnesium-glycinate 
6. Schuette SA, Lashner BA, Janghorbani M. Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. J Parenter Enteral Nutr. 1994 Jul-Aug;18(4):430–435. PMID: 23853635.
7. Medina JR, Sant’Anna M, da Rocha H. Alterações metabólicas no défice de creatina. Medicina Biomolecular. 2008 [cited 2025 Sep 29]. Available from: http://www.medicinabiomolecular.com.br/biblioteca/pdfs/Doencas/do-1848.pdf 
8. Firoz M, Graber M. Bioavailability of US commercial magnesium preparations. Magnes Res. 2001 Jun;14(4):257–262. PMID: 27402922. 
9. Gröber U, Schmidt J, Kisters K. Magnesium in prevention and therapy. Nutrients. 2015 Sep;7(9):8199–8226. doi:10.3390/nu7095388. PMID: 26404370; PMCID: PMC5986461. 
10. Lindberg JS, Zobitz MM, Poindexter JR, Pak CY. Magnesium bioavailability from magnesium citrate and magnesium oxide. J Am Coll Nutr. 1990 Oct;9(1):48–55. PMID: 17645588. 
11. Walker AF, Marakis G, Christie S, Byng M. Mg citrate found more bioavailable than other magnesium preparations in a randomised, double-blind study. Magnes Res. 2003 Dec;16(3):183–191. PMID: 19968914. 
12. Cuciureanu MD, Vink R. Magnesium and stress. In: Vink R, Nechifor M, editors. Magnesium in the central nervous system. Adelaide: University of Adelaide Press; 2011. p. 1–11. PMID: 19271946. 
13. Black RE, Victora CG, Walker SP, et al. Maternal and child undernutrition and overweight in low-income and middle-income countries. Matern Child Nutr. 2013 Jan;9(Suppl 2):59–82. doi:10.1111/j.1740-8709.2012.00440.x.
14. Barbagallo M, Dominguez LJ. Magnesium and aging. Curr Pharm Des. 2010;16(7):832–839. PMCID: PMC3208934. Pharmacy Times. Study: half of all Americans are magnesium deficient. 
15. Pharmacy Times. 2022 [cited 2025 Sep 29]. Available from: https://www.pharmacytimes.com/news/study-half-of-all-americans-are-magnesium-deficient Health.com Editors. 
16. NHS. Vitamins and minerals: others. NHS. 2024 [cited 2025 Sep 29]. Available from: https://www.nhs.uk/conditions/vitamins-and-minerals/others/ Root Functional Medicine. Magnesium citrate vs magnesium glycinate. 
17. Root Functional Medicine. 2024 [cited 2025 Sep 29]. Available from: https://rootfunctionalmedicine.com/magnesium-citrate-vs-magnesium-glycinate 
18. Rude RK. Magnesium deficiency: a cause of heterogenous disease in humans. J Bone Miner Res. 2012 Oct;27(10):2049–2056. PMCID: PMC6683096. 
19. Takahashi N, Morimoto S, Okamoto K, et al. Magnesium supplementation in the treatment of hypertension: a randomized, double-blind, placebo-controlled trial. Hypertens Res. 2010 Apr;33(4):366–372. PMID: 30761462.
 

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